Clonality of lobular carcinoma in situ and synchronous invasive lobular carcinoma

Clonality of lobular carcinoma in situ and synchronous invasive lobular carcinoma.

BACKGROUND Lobular carcinoma in situ (LCIS) of the breast is considered a marker for an increased risk of carcinoma in both breasts. However, the frequent association of LCIS with invasive lobular carcinoma (ILC) suggests a precursor-product relation. The possible genomic relation between synchronous LCIS and ILC was analyzed using the technique of array-based comparative genomic hybridization ...

Relapse of invasive lobular carcinoma.

Bilateral male breast cancer: a case presenting with synchronous invasive lobular carcinoma and invasive ductal carcinoma

Synchronous bilateral male breast cancer is a very rare entity and invasive lobular carcinoma is less common in male breast cancer (MBC) than in female breast cancer (FBC). A 51-year-old man presented with a palpable mass in the left breast was finally diagnosed synchronous bilateral MBC, one an invasive lobular carcinoma and the other an invasive ductal carcinoma. It remains a matter of debate...

Genetic relation of lobular carcinoma in situ, ductal carcinoma in situ, and associated invasive carcinoma of the breast.

AIMS The mutual relation of lobular carcinoma in situ (LCIS) and ductal carcinoma in situ (DCIS) of the breast, as accepted precursor lesions of invasive breast cancer, is controversial. Because they display genetic heterogeneity, it is not clear how genetically advanced these entities are and what causes the transition to an invasive carcinoma. METHODS Six cases of LCIS, four of them with as...

Invasive lobular carcinoma of the breast.

The classical pattern of invasive lobular carcinoma (ILC) has become well established since the tumour was first designated in the 1940's. It is a distinct histological type of breast cancer, yet the incidence rates accumulated from the literature are widely divergent and vary from 0.7-20 per cent,' suggesting the criteria for diagnosis are not well defined. Martinez and Azzopardil in the only ...